Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum

Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum

Erythema Nodosum Leprosum (ENL) is an immune reaction in leprosy that aggravates the patient´s clinical condition. ENL presents systemic symptoms of an acute infectious syndrome with high leukocytosis and intense malaise clinically similar to sepsis. The treatment of ENL patients requires immunosuppression and thus needs to be early and efficient to prevent both disabilities and permanent nerve...

Complement C1q expression in Erythema nodosum leprosum

Complement C1q is a soluble protein capable of initiating components of the classical pathway in host defence system. In earlier qualitative studies, C1q has been implicated in the pathogenesis of Erythema Nodosum Leprosum (ENL). However, little is known about the role of this complement in ENL reaction. In the present study we described the protein level of C1q production and its gene expressi...

Erythema nodosum leprosum.

Etanercept in erythema nodosum leprosum*

One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of sid...

Clinical observations on erythema nodosum leprosum (E.N.L.).

The nodules were sometimes the exacerbation of existing lesions, or sometimes the eruption of fresh lesions. The nodules themselves varied from about the size of a pea to about the size of a shilling, and they were usually tender on pressure. Ankaful Leprosarium is the headquarters of the Ghana Leprosy Service and is situated 6 miles from the coast and is 1 00 miles west of Accra. It admits pri...